Ketoosi ei välttämättä ole kovin hyvä idea. Atkinsin dietti nostaa voimakkaasti veren metyyliglyoksaalia. Tästähän ikääntymisguru Aubrey be Greykin mainitsi joskus aiemmin. Myöskään korkeaproteiiniset dietit ei välttämättä ole kovin hyviä, koska koe-eläimienkin elinaika lyhenee niillä eläinkokeissa.
Ketosis leads to increased methylglyoxal production on the Atkins diet
In the popular and widely used Atkins diet, the body burns fat as its main fuel. This process produces ketosis and hence increased levels of beta-hydroxybutyrate (BOB) acetoacetate (AcAc) and its by-products acetone and acetol. These products are potential precursors of the glycotoxin methylglyoxal. Since methylglyoxal and its byproducts are recognized as a significant cause of blood vessel and tissue damage, we measured methylglyoxal, acetone, and acetol in subjects on the Atkins diet. We found that by 14-28 days, methylghyoxal levels rose 1.67-fold (P = 0.039) and acetol and acetone levels increased 2.7- and 6.12-fold, respectively (P = 0.012 and 0.028). Samples from subjects with ketosis showed even greater increases in methylglyoxal (2.12-fold), as well as acetol and acetone, which increased 4.19- and 7.9-fold, respectively; while no changes were seen in samples from noncompliant, nonketotic subjects. The increase in methylglyoxal implies that potential tissue and vascular damage can occur on the Atkins diet and should be considered when choosing a weight-loss program.
Health is a crown worn by the healthy people on their heads.