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Polikosanoli

polikosanoli kolesteroli LDL

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#1 Blueteam

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Lähetetty 11 toukokuu 2013 - 11:01

Tämä on kasvivahauutetta, josta on vähän ristiriitaista näyttöä kolesterolin alennuksessa.

 

http://www.ncbi.nlm....pubmed/23302671

RESULTS:

(1) After 16 weeks, all parameters remained unchanged in the placebo group; the level of TC decreased from (7.01 ± 1.03) mmol/L to (5.66 ± 0.83) mmol/L (-19.4%, P < 0.01), the level of LDL-C decreased from (4.78 ± 0.72) mmol/L to (3.70 ± 0.69) mmol/L (-22.5%, P < 0.01) in the treatment group. TG and HDL-C levels remained unchanged (P > 0.05) while the level of HO-1 significantly decreased from (1.82 ± 1.08) µg/L to (1.45 ± 0.81) µg/L (P < 0.01) and the level of hs-CRP decreased from (3.40 ± 3.64) mg/L to (1.86 ± 2.02) mg/L (P < 0.01) in the treatment group. (2) Safety index was similar between placebo and treatment groups (P > 0.05) and there was no adverse events including allergic reaction, muscle pain in all subjects during the observation period.

CONCLUSION:

The short-term data obtained from this small hyperlipidemia patient cohort suggest that policosanol is a safe lipid-lowering and anti-inflammatory agent for hyperlipidemia patients.

 

http://www.ncbi.nlm....pubmed/16705107

RESULTS:

A total of 143 patients were randomized to 5 equal groups and were analyzed on an intention-to-treat basis. In none of the 5 treatment groups did LDL-C levels decrease more than 10% from baseline. No statistically significant difference between policosanol and placebo was observed. A nonparametric test analyzing dose-dependency yielded nonsignificant results. In none of the secondary outcome measures, namely total cholesterol, high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol, triglycerides, lipoprotein(a), and ratio of total or LDL-C to HDL-C, were there any significant effects of policosanol. Policosanol was tolerated well without serious adverse events.

CONCLUSION:

In patients with hypercholesterolemia or combined hyperlipidemia, the sugar cane-derived policosanol in usual and high doses does not demonstrate a reduction in lipid levels beyond placebo.

 

 

iHerbissäkin on tätä myynnissä:

 

http://www.iherb.com...ggie-Caps/11497

http://www.iherb.com...mg-90-Vcaps/743

http://www.iherb.com...60-Tablets/4859


Health is a crown worn by the healthy people on their heads.

#2 Blueteam

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Lähetetty 13 toukokuu 2013 - 03:23

Kuubalaisten tutkimusten mukaan polikosanoli on toimivaa ainetta. 20mg annos näyttäisi tuovan lähes saman hyödyn kuin 40mg.

 

http://www.ncbi.nlm....pubmed/11708574

Policosanol is a well defined mixture of higher aliphatic primary alcohols isolated from sugar cane wax with cholesterol-lowering effects proven for a dose range from 5-20 mg/day in patients with type II hypercholesterolemia and dyslipidemia associated with noninsulin dependent diabetes mellitus. This randomized, double-blind study investigated the cholesterol-lowering efficacy and tolerability of policosanol 20 mg/day compared with 40 mg/day. Changes in low-density lipoprotein (LDL)-cholesterol levels were predefined as the primary efficacy endpoint. Patients with type II hypercholesterolemia were enrolled in the study and instructed to continue a step I cholesterol-lowering diet for 6 weeks and those eligible to be included (89) were randomly allocated to receive under double-blind conditions placebo (n = 30), policosanol 20 mg/day (n = 29) or 40 mg/day (n = 30). After 24 weeks, policosanol at 20 and 40 mg/day significantly (p < 0.00001) lowered LDL-cholesterol by 27.4% and 28.1%, total cholesterol (p < 0.00001) by 15.6% and 17.3%, and the LDL-cholesterol/high-density lipoprotein (HDL)-cholesterol ratio by 37.2% and 36.5%, respectively The ratio of total cholesterol/HDL-cholesterol was lowered by 27.1% and 27.5%, while HDL-cholesterol levels increased (p < 0.001) by 17.6% and 17.0%, respectively. Compared with baseline, policosanol 20 mg/day lowered triglycerides (p < 0.05) by 12.7%, while they were lowered (p < 0.01) by 15.6% at a dose of policosanol 40 mg/day All the above-mentioned significant differences were also different from placebo and no significant changes occurred in any lipid profile parameters in the placebo group. Based on the mean values of LDL-cholesterol levels at study completion, the mean percent reductions from baseline were 27.4% and 28.1% for the 20 and 40 mg/day groups, respectively. Thus, the effects of both policosanol doses on the main efficacy variable were practically identical. Consistent with the data obtained for LDL-cholesterol, both doses were similarly effective in changing all the other lipid profile parameters. No unexpected adverse effects were observed and there were no significant between-group differences regarding safety indicator values or reported adverse effects. In conclusion, although the tolerability profile remains excellent, according to the present results policosanol at a dose of 40 mg/day does not offer significant additional cholesterol-lowering efficacy over the 20 mg/day dose.


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#3 Blueteam

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Lähetetty 10 lokakuu 2013 - 15:43

http://jama.jamanetw...rticleid=202869

 

Polikosanoli näyttää joltain Fidel Castron salajuonelta pahoja länsimaisia statiineja vastaan. :)

 

Virtually all of the published scientific literature supporting the beneficial effects of policosanol on lipids has been authored by a single research group from Cuba. In 2002, we reviewed the existing literature and have stressed the need for independent confirmation of these results.1 A recent meta-analysis of natural therapies for hyperlipidemia concluded that policosanol has lipid-lowering properties more effective than plant sterols.2 In summary, the study shows that the low-density lipoprotein cholesterol (LDL-C) lowering effects of sugar cane–derived policosanol are similar to the effects of statins but are achieved without adverse effects.

Until 2004, trials outside of Cuba studying its effectiveness are lacking with the exception of 2 studies.3,4 All trials of the lipid-lowering effects have used policosanol manufactured by 1 company in Cuba and an astonishing consistency exists between the Cuban results of individual studies. Therefore, independent verification from studies outside Cuba on the Cuban policosanol, studies of Cuban and other policosanols in non-Hispanic populations, and studies lasting at least 12 weeks are necessary. The Cuban findings have been challenged by a clinical trial from the Netherlands that showed that a standard dose (20 mg/d) wheat germ–derived policosanol is ineffective in lowering total cholesterol and LDL-C.

 

Recently, a systematic review of the literature up to June 2003 of randomized controlled trials using policosanol was published.2 Concerning the primary end point of reduction of LDL-C, this meta-analysis found 29 eligible studies with 1528 patients receiving treatment compared with 1406 patients receiving placebo. Twenty-eight of the 29 trials came from Cuba and 1 trial came from Argentina.15 Weighted estimates of percentage change in LDL-C were –23.7% for policosanol (mean dose of policosanol, 12 mg/d; range, 5-40 mg/d) vs –0.11% for placebo (P<.001). This LDL-C reduction is well in the order of magnitude that is achieved with commonly used doses of statins.16 In fact, some trials, again all but 1 from Cuba, directly compared the effects of policosanol with statins3,1721 and found policosanol equally effective or better. Even a dose of policosanol as low as 2 mg/d was found to lower LDL-C significantly by more than 15%.22 It has been suggested that the lipid-lowering effects of policosanol are dose-dependent from 2 to 40 mg/d.23

The reasons for the discrepant results between our trial and previous studies are unclear. As nearly all previous studies have been performed in Latin America (1 positive study was performed in Russia),4 it cannot be excluded that either ethnic or nutritional factors contribute to the impressively potent lipid-lowering effects of policosanol reported. Although ethnic and nutritional differences between European white and Latin American patients might play a role, the magnitude of differences reported (no effect vs a consistent 25% LDL-C reduction) makes this explanation unlikely. Furthermore, other lipid-lowering drugs, such as statins24 and ezetimibe25 have been shown to have no ethnic-specific effects. The same holds true for responses to low-fat diet.26

Almost all studies were supported by 1 sponsor, Dalmer Laboratories, a commercial enterprise founded by the Center of Natural Products, National Center for Scientific Research, La Habana, Cuba, to market policosanol. Our group1 and other studies5,23 have therefore suggested that independent studies should be performed to prove the efficacy of policosanol. Until now, independently performed studies are scarce. Our trial is the first study to investigate sugar cane–derived policosanol independently from the aforementioned Cuban research group but still using Cuban policosanol. A randomized placebo-controlled trial from the Netherlands of 58 patients found no effects when using wheat germ policosanol (20 mg/d) on lipoproteins in patients with normal to mildly increased cholesterol.5 Very few other studies outside Cuba exist but are not convincing in quality. An animal study performed in Canada in hamsters showed that sugar cane and rice wax policosanol have no effects on lipids,27 which is in contrast with findings of a variety of animal studies from Cuba.28,29 The putative mechanism of action of policosanol has not been clarified, although suppression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase activity has been postulated.30


Health is a crown worn by the healthy people on their heads.





myös merkitty yhdellä tai useammalla näistä avainsanoista: polikosanoli, kolesteroli, LDL

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