Heran laktoferriini vähentää makrofaagien LDL-kolesterin ottoa ja tätä kautta ateroskleroosia.
Lactoferrin is an iron-binding protein which has been shown to reduce uptake of LDL cholesterol by macrophages — and hence reduce the foam-cell formation of atherosclerosis.
Heraa syövillä rotilla oli alhaisempi VLDL kuin kaseiinia tai soijaa syövillä.
Rats fed high levels of whey protein showed reduced plasma VLDL cholesterol & liver cholesterol in contrast to diets of casein & soya-bean protein. Lower levels of whey only reduced liver cholesterol. The effect of whey protein was explained by reduced whey-protein binding of bile acids.
Heraa syövät koe-eläimet syövät myös vähemmän kaloreita.
Interestingly (to a person attempting CRAN), the whey-fed rates ate less than the casein-fed rats. [BRITISH JOURNAL OF NUTRITION 70:139-146 (1993)]
Heraa syövät hiiret ja hamsterit elivät selvästi perusravinnolla olevia kauemmin.
A 6-month study on mature mice showed a 30% increase in mean survival time of whey-fed mice, in contrast to those fed "nutritionally-equivalent Purina mouse chow" [CLINICAL AND INVESTIGATIVE MEDICINE 12:343-349 (1989)]. Full-lifespan studies on Syrian hamsters showed a dramatic increase in lifespan with animals on varying levels of lactalbumin, in contrast to a commercial diet:
Hera buustaa immuniteettia paremmin kuin proteiinit seuraavista lähteistä: kaseiini, soija, vehnä, maissi, kananmunan valkuainen, kala, liha, spirulina, scenedesmus-levä.
Although protein-calorie restriction experiments extended the life of animals kept in highly sterile conditions, resistance to infection was depressed in these animals. The humoral immune response of a 20-gram (protein)/100-gram (dietary total) whey-protein diet was demonstrated to be significantly higher than that of a 20-gram/100-gram portion of protein from either of casein, soy, wheat, corn, egg-white, fish, beef, Spirulina maxima, Scenedesmus algae or Purina mouse chow [noted in CLINICAL AND INVESTIGATIVE MEDICINE 11(3):213-217 (1988)]. The clonal expansion & antibody production required for the humoral immune response demands availability of amino acids for protein synthesis
Whey protein contains 8 times more of the amino-acid cysteine than casein. Cysteine administered directly into cells increases the synthesis of the tripeptide glutathione — which, in turn, enhances lymphocyte DNA synthesis. But the humoral response of mice fed a whey protein diet was found to be 5 times greater than for a diet of either pure casein or casein enriched with cysteine [CELLULAR IMMUNOLOGY 97:155-163 (1986) and CLINICAL AND INVESTIGATIVE MEDICINE 11(4):271-278 (1988)].
Hera ja kaseiini nostaa maksan glutationia yli tuplasti tehokkaammin kuin soija.
Glutathione (GSH) is a tripeptide composed of the amino acids cysteine, glycine and glutamic acid (gamma-glutamyl-cysteinyl-glycine). Cysteine is toxic outside of cells, and is not readily transported into cells. Inside cells, cysteine alone does not increase synthesis of glutathione as much as the dipeptide glutamyl-cysteine. Dietary glutamyl-cysteine is also believed to increase cellular cysteine much more than dietary cysteine. The whey proteins beta-lactoglobulin, serum albumin and lactoferrin are especially rich in glutamyl-cysteine. Liver glutathione concentrations have been shown to be more than twice as high in whey & casein-fed rats than in soyabean-protein fed rats. [JOURNAL OF NUTRITION 125:809-816 (1995)].
Glutationi vaikuttaa kaikkeen. Esim. silmät se pitää kunnossa. Heraproteiini piti myös syöpää sairastavat hiiret elossa kokeessa, jossa 66% tavallista ruokaa syövistä hiiristä kuoli.
Glutathione concentration in liver, kidney, heart and brain are 30%, 34%, 20% and 30% lower (respectively) in elderly mice than in mature mice [CLINICAL AND INVESTIGATIVE MEDICINE 14(4):296-309 (1991)]. Glutathione concentrations in the eye are normally very high, and the lens even possesses a transport mechanism to facilitate GSH uptake. Decreasing glutathione levels in the lens due to aging is associated with cataract formation [CURRENT EYE RESEARCH 3(1):83-87 (1984)]. In an experiment on the induction of colon cancers in mice, all animals fed whey protein were still alive at the end of the experiment, in contrast to only 66% still living of those who had been fed casein or Purina diet [TUMOR BIOLOGY 11:129-136 (1990)].
Thus, by providing high quality protein, whey boosts the immume system, prevents muscle wasting, and maintains adequate protein nutrition. Moreover, the antioxidant effects of increased glutathione may be the basis for the increased lifespan seen with whey protein in some animal studies.